Search
Now showing items 1-10 of 161
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Strategies to improve macroencapsulated islet graft survival
(2007-10-05)
Chronic immunosuppressive therapy may have severe side-effects. In cell
transplantation, the graft can be encapsulated within a membrane chamber,
providing a physical barrier against the immune system. The cell graft
then ...
Psychosocial work conditions and musculoskeletal complaint : the role of affective stress response as a mediator of the effect of psychosocial risk factors on musculoskeletal complaints
(2007-11-22)
The hypothesis tested in these two studies was that unfavourable
psychosocial work conditions are expected to increase the risk of
musculoskeletal complaints (MSC), and that this effect is at least partly
mediated by ...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
+RA (RR=1.7, 95% CI=1.1-2.6) was observed after exposure to hydraulic oil. The number of women occupationally exposed to mineral oils was too few to allow meaningful analyses. Association between cosmetic usage and the risk of developing RA was also...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
from HIV-1 infected subjects. In paper II and III, tonsillar B cells were infected with EBV and the expression of CXCR4, CXCR5 and CCR7 was followed over time. Already two days after infection, a decrease of surface CXCR4, CXCR5 and CCR7 was detected...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Molecular genetics of cutaneous malignant melanoma
(2007-08-24)
Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the
skin with rapidly increasing incidence. Patients with advanced disease
have a poor prognosis since the tumor is usually resistant to current
therapies. ...