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Molecular epidemiology of pneumococcal carriage and invasive disease
(2007-02-02)
isolates from the same period of time and the same
geographic area were compared. Depending on serotypes the isolates could
be grouped into at least two classes. One class caused mainly invasive
disease (serotype 1, 4, 7F and 9V) and the other class...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...
Repressing the hedgehog signalling pathway
(2007-11-28)
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal ...
Molecular mechanisms of estrogen action in relation to metabolic disease
(2007-11-16)
Estrogens have multiple effects on the body. Most studied are the
effects on female reproduction. In this thesis, we have focused on the
metabolic effects of estrogens. Estrogen treatment decreases adipose
tissue mass ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...