Search
Now showing items 1-10 of 241
p73 : regulator of differentiation and apoptotic cell death
(2007-05-04)
Neoplasia is characterized by cells' loss of self-control due to
deregulated apoptotic and cell proliferation pathways. Anticancer
treatments aim to induce either cell cycle arrest or apoptosis, and these
effects are ...
Gene regulation and immune mechanisms in multiple sclerosis experimental models
(2007-09-04)
-EAE was exacerbated in mice that lacked TLR4, TLR4 signaling decreased IL-6 and IL-23 production and TLR4-/- mice had a higher frequency of splenic Th17 cells and more sera IL-17. TLR9-/- mice developed more severe MOGEAE and higher IL-17 levels than WT mice...
Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat
(2007-05-25)
)
in separate groups of awake rats.
Robalzotan (0.3; 1 and 3 µmol/kg s.c.) caused a dose-dependent increase
of extracellular ACh levels in the rat FC to a maximal value of about
210-280% of controls at the highest dose. ACh concentrations returned...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Cataract induced by UVR-B 300nm : characterization and genetic modulation of the lens sensitivity to oxidative stress
(2008-03-28)
Cataract is defined as an opacification of the lens resulting in visual
impairment. Worldwide, it is the number one cause of blindness and there
are currently no strategies to prevent the onset of the disease. Cataract
surgery ...
Liquid chromatography : mass spectrometry study of two biochemical alcohol markers
(2007-03-09)
The interest in biochemical alcohol markers for detecting acute and
chronic alcohol consumption has expanded greatly during recent years. The
development and application of laboratory tests identifying early
problematic ...