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On the pro-apoptotic signaling induced by interferon-alpha
(2007-04-06)
Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used
as an active drug in the treatment of malignant diseases for almost five
decades. It has shown beneficial results in several hematological
malignancies, ...
Perceived allergy and hypersensitivity – especially food hypersensitivity – and the consequences for children, adolescents and their families
(2007-10-26)
Background: Allergy and hypersensitivity are growing health issues with impact on the individual’s physical and psychosocial quality of life, work and social life. This thesis focuses on children and adolescents with ...
Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
activity in five glioblastoma cell lines (MO59J, MO59K, 8, 18 and 38).
The ability of the ionizing radiation to improve the effect of the
molecular targeted therapy was also investigated. Interaction between
small inhibitors and ionizing radiation...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...