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In vitro models to study mechanisms of neural cell death induced by toxic agents
(2007-11-29)
Neurotoxicity arises when exposure to toxic agents, either naturally
occurring or manmade substances, alters the normal activity and/or
structure of the nervous system. This can lead to disruption of vital
metabolic processes ...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Insulin-like growth factor binding protein-3 : structure and function
(2007-11-02)
in the circulation. We have studied posttranslational modification of IGFBP-3, such as proteolysis and glycosylation, and their impact on IGF binding and actions. The IGFBPs have IGF binding sites in the N- and C-terminal domains. Prior to this thesis the binding...
Knowledge acquisition in patients with heart disease
(2007-09-07)
The general aim was to evaluate different aspects of the knowledge
acquisition process in patients with heart disease. Three different
education programs were evaluated.
In Paper I 208 patients with systolic heart failure ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
Environmental factors are likely contributing factors in the development of Rheumatoid Arthritis (RA), an autoimmune disease, for which etiologic factors are still poorly known. Mineral oils are efficient adjuvants which ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Effects of endurance exercise on mitochondrial efficiency, uncoupling and lipid oxidation in human skeletal muscle
(2006-12-29)
of uncoupling protein 3 (UCP3), but the functional role of UCP3 in non-coupled respiration is not completely understood. The aim of this thesis was to investigate mitochondrial efficiency (P/0 ratio), mitochondrial fat oxidation, noncoupled respiration (state 4...