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Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat
(2007-05-25)
The aim of the thesis was to investigate the effects of the 5-HT1A
receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor
antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl)
oxymethyl-morpholine ...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Mother and newborn adaptations after birth : influence of administration of oxytocin and epidural analgesia during labour
(2009-08-31)
Aims: This thesis explores postpartum physiological and psychological adaptations in mothers and newborns in the short-and long-term perspective. The thesis further explores the influence of labour ward interventions, such ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Knowledge acquisition in patients with heart disease
(2007-09-07)
The general aim was to evaluate different aspects of the knowledge
acquisition process in patients with heart disease. Three different
education programs were evaluated.
In Paper I 208 patients with systolic heart failure ...
Truncation and missing family links in population-based registers
(2008-03-07)
Studies of familial aggregation of disease routinely use linked
population registers to construct retrospective cohorts. Although such
resources have provided numerous estimates of familial risk, little is
known regarding ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
From stem cells to neurons : a BMPy ride
(2007-10-05)
neural specification, BMP4 promotes astrocytic while inhibiting oligodendrocytic cell fates, an activity by BMP4 also seen in NSCs. Furthermore, the differentiation downstream of BMP4 in NSCs is dependent on the cell density, inducing mesenchymal...