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Predictors of cognitive decline in memory clinic patients
(2007-05-18)
Background: The major challenge in memory clinics is to predict
development as well as non-development of dementia among the
heterogeneous group of patients with cognitive complaints. Since the
advent of pharmacological ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
out at pH 5.7. The pathway of this base flipping is studied. We demonstrate that the minor groove pathway is preferred over the major groove pathway, and that protonation on an A adjacent to the flipping U lowers the energy barrier ~3.5 kcal...
Mother and newborn adaptations after birth : influence of administration of oxytocin and epidural analgesia during labour
(2009-08-31)
: 1) mothers who had received intravenous oxytocin during labour (OT iv group, n=10), 2) mothers who had received oxytocin intramuscularly after birth to prevent postpartum haemorrhage but no other treatment (OT im group, n=15) and 3) mothers who had...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
binding motifs in the hTERT promoter and is required for maintenance of histone H3-K4 trimethylation in this region. Knocking down SMYD3 in some tumor cell lines abolished trimethylation of H3-K4, attenuated the occupancy by the transactivators c...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Insulin-like growth factor binding protein-3 : structure and function
(2007-11-02)
in the circulation. We have studied posttranslational modification of IGFBP-3, such as proteolysis and glycosylation, and their impact on IGF binding and actions. The IGFBPs have IGF binding sites in the N- and C-terminal domains. Prior to this thesis the binding...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...