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Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
(2007-09-07)
acidification leads to dissolution of mineral, and secretion of
proteolytic enzymes e.g. cathepsin K (Ctsk) and matrix metalloproteinase
(MMP)-9 completes degradation of the exposed collagen. Another secreted
osteoclast enzyme, tartrate-resistant acid...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Economic burden of diabetes on patients and their families in Sudan
(2007-11-27)
childhood was USD 283 per diabetic child, of which 36% was spent on insulin. The direct median cost of diabetes care of type 2 adult diabetes patients was USD 175 per year, which included the cost of drugs and ambulatory care. These costs represent 23% and 9...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Misoprostol : pharmacokinetics and effects on uterine contractility and cervical ripening in early pregnancy
(2007-08-17)
Misoprostol is an orally active synthetic PGE1 analogue which has become
an important drug in obstetric and gynaecological practice because of its
uterotonic and cervical priming actions. It is safe, cheap, widely
available ...