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Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Involvement of evolutionarily plastic regions in cancer associated CHR3 aberrations
(2007-05-04)
lead of our study, we have analyzed a putative tumor
suppressor gene LIMD1, which is located within the deleted central part
of CER1. We found that it binds specifically to pRb and suppresses E2F
driven transcription. A tumor suppressor effect...
Functional and diagnostic aspects on adrenocortical adenoma
(2007-04-13)
expression of the steroid synthesizing enzymes and thereby identify the steroid production of adrenocortical adenoma. In vitro release of aldosterone and cortisol from thin slices was compared to the mRNA expression of CYP11B2, CYP11B1 and CYP17, which...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
, the effects of sensitizing tumor cells to cisplatin by inhibition of their energy production are investigated. Both an inhibitor of glycolysis, 2-deoxyglucose (DG) as well as an inhibitor of fatty acid â oxidation, etomoxir, were shown to potentiate...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Role of estrogen receptor beta in epithelia lacking estrogen receptor alpha expression
(2008-04-18)
Estrogens influence the physiology of many organs by activation of the nuclear receptors ERalpha and ERbeta. The epithelium of ventral prostate, ovarian granulosa cells and lung, are ERalpha-negative but express high levels ...
Molecular genetics of cutaneous malignant melanoma
(2007-08-24)
study, we investigated the occurrence of activating
mutation in the NRAS gene in a subset of patients with hereditary
melanoma carrying germ line CDKN2A alterations. From this study we found
differences in the frequency of NRAS mutations between...