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Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat
(2007-05-25)
was observed between 20-40 min
after the drug administration, reaching 217 % of control values at a
higher dose. However, the ACh levels maintained elevated during the
entire post-injection sampling period (180 min). Robalzotan (75 or 100 µM
perfused locally...
Method specific factors in personality tests
(2007-09-21)
Two of the most widely used personality assessment methods are the
Rorschach (Exner, 1993) and the MMPI/MMPI-2 (Hathaway & McKinley, 1943;
1989). Both methods have demonstrated validity for particular purposes
(Meyer & ...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
out at pH 5.7. The pathway of this base flipping is studied. We demonstrate that the minor groove pathway is preferred over the major groove pathway, and that protonation on an A adjacent to the flipping U lowers the energy barrier ~3.5 kcal...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Liquid chromatography : mass spectrometry study of two biochemical alcohol markers
(2007-03-09)
The interest in biochemical alcohol markers for detecting acute and
chronic alcohol consumption has expanded greatly during recent years. The
development and application of laboratory tests identifying early
problematic ...
Analysis of neuropathic pain after spinal cord injury
(2008-01-18)
Longstanding neuropathic pain is a challenge in spinal cord injury (SCI) rehabilitation. Once established it is difficult to treat successfully. Neuropathic pain has a negative influence on quality of life and on the outcome ...