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Genomic and transcripto variation in blood stage Plasmodium falciparum
(2007-08-31)
isogenic clones
with distinct adhesive and antigenic phenotypes (rosettes formation for
3D7S8.4 and CD36 binding for 3D7AH 1 S2) were isolated by
micropanipulation. To have a global view of gene expression governing
their phenotypes, we have employed a P...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
to become ex-posed to ethanol following ingestion. In this thesis I explored their reactions to ethanol and EtP in the setting of an acute inflammatory reaction, e.g. after challenge with LPS, IL-1, TNFalpha or LTB4 mimicking, for instance, sepsis...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
Proinflammatory factor mediated lymphocyte activation-the pivotal role of leukotriene B4
(2007-11-06)
-gamma
to the NK cell depleted cultures.
Further we demonstrated that leukotriene B4 (LTB4) was involved in the
effect of the PSK and Trx80. LTB4 was detected in the medium, and T cell
activation was compromised by addition of leukotriene biosynthesis
inhibitors...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Cataract induced by UVR-B 300nm : characterization and genetic modulation of the lens sensitivity to oxidative stress
(2008-03-28)
Cataract is defined as an opacification of the lens resulting in visual
impairment. Worldwide, it is the number one cause of blindness and there
are currently no strategies to prevent the onset of the disease. Cataract
surgery ...