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Molecular imaging of the serotonin system in human behaviour
(2007-02-16)
The serotonin (5-HT) neurotransmission system has a role in essential
physiological and psychological functions such as sleep, eating
behaviour, sexuality, perception, emotion and cognition. Individual
measures of serotonin biomarkers in the living...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Knowledge acquisition in patients with heart disease
(2007-09-07)
The general aim was to evaluate different aspects of the knowledge
acquisition process in patients with heart disease. Three different
education programs were evaluated.
In Paper I 208 patients with systolic heart failure ...
In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5
(2007-11-27)
culture systems were investigated as in vitro
models for tau phosphorylating kinases, with an emphasis on
cyclin-dependent kinase-5 (Cdk5).
In paper I, differentiated SH-SY5Y cell line was investigated as a model
for tau phosphorylation. Sequential...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due ...
Clinical studies of biomarkers in suicide prediction
(2007-10-19)
of two biomarkers: the nonsuppression in the dexamethasone suppression test (DST) and low 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid(CSF) in suicide prediction in clinical high-risk groups and to investigate relationships of the two...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
Environmental factors are likely contributing factors in the development of Rheumatoid Arthritis (RA), an autoimmune disease, for which etiologic factors are still poorly known. Mineral oils are efficient adjuvants which ...