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Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins
(2007-05-11)
Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The
main pathology is characterized by progressive degeneration of the
dopaminergic (DA) neurons of the substantia nigra leading to loss of
striatal ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
to become ex-posed to ethanol following ingestion. In this thesis I explored their reactions to ethanol and EtP in the setting of an acute inflammatory reaction, e.g. after challenge with LPS, IL-1, TNFalpha or LTB4 mimicking, for instance, sepsis...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...