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Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Mdm2 phosphorylations : characterization and applications
(2007-09-07)
Cancer is a widespread disease. In spite of all research resulting in new
improved therapies, there are still many tumors that cannot be cured. To
oppose that, also a preventive research approach is important with ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Molecular mechanisms of estrogen action in relation to metabolic disease
(2007-11-16)
Estrogens have multiple effects on the body. Most studied are the
effects on female reproduction. In this thesis, we have focused on the
metabolic effects of estrogens. Estrogen treatment decreases adipose
tissue mass ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
the levels of the expression of phosphorylated IGF receptor type 1 (p-IGF1R), caspase-3, Bcl-2, and IGFBP-3 in Leydig cells at different stages of development. The IGF receptor type 1(IGF1R) are expressed primarily in the adult testis and IGF-I participates...
Transcriptional regulation by inner nuclear membrane proteins
(2007-04-19)
, bind promoters of SPS-sensor regulated genes and induce their transcription. Recessive loss-of-function mutations in ASI1, ASI2 and ASI3 (amino acid sensor independent) genes bypass the requirement of a functional SPS-sensor and constitutively induce...