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Cutaneous lupus erythematosus and immunoreactivity in patients with Ro/SSA autoantibodies
(2006-12-26)
Lupus crythematosus (LE) is a heterogenous autoimmune disorder with many different clinical presentations. Cutaneous lupus erythematosus (CLE) is subdivided into acute, subacute and chronic CLE. Population-based epidemiologic ...
Arthroplasty in patients with femoral neck fractures
(2011-05-03)
The aim of this thesis was to analyze hip function and the health-related quality of life (HRQoL) in patients with a displaced fracture of the femoral neck treated with a cemented total hip arthroplasty (THA) or a ...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Cognitive functions in depression and anxiety disorders : findings from a population-based study
(2006-11-10)
This doctorial thesis examines cognitive functions in depression and anxiety disorders in a populationbased sample that includes mostly untreated persons. It is well established that depression is associated with cognitive ...
Genetic and molecular determinants in inflammatory bowel disease
(2006-11-21)
Inflammatory Bowel Disease, IBD, are polygenic disorders that present itself to the clinician as a sum of interacting events arising from multiple factors of genetic, immunological and environmental origin, resulting in a ...
Genetic epidemiological studies of adverse pregnancy outcomes and the role of schizophrenia
(2006-02-24)
The purposes of this thesis were to investigate the importance of genetic and environmental factors in the development of adverse pregnancy outcomes and to investigate the role of schizophrenia as a risk factor for and a ...
Streptococcus pyogenes infections and toxic shock syndrome : molecular epidemiology and immunotherapy
(2006-03-08)
in neutralising the superantigens. Most supernatants were completely inhibited at concentrations between 0.5 - 2.5 mg IVIG/ml. Importantly, culture supernatants from S. pyogenes isolates were consistently inhibited to a higher extent as compared to those of S...
Role of the OX40 ligand/receptor pair in coronary artery disease
(2006-11-17)
Atherosclerosis is the pathological basis for coronary artery disease (CAD), the leading cause of morbidity and mortality in developed countries. CAD and atherosclerosis have long been known to have a familial component ...
Drug use among the very old living in ordinary households : aspects on well-being, cognitive and functional ability
(2007-02-28)
gender (OR: 2.8; 95% CI: 1.2-6.5) was the only variable associated with regular use of medicines. The results also showed that older age and functional disability as measured by ADL, increased the risk of receiving help with medicines, while higher...
Selenium compounds as a novel class of experimental cancer chemotherapeutics
(2021-02-25)
Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a ...