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Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
catalyzed by cytochrome P450 (CYP) enzymes. The main enzyme in its activation is CYP2B6 that has a polymorphic gene. Several studies have reported high degree of inter- and intraindividual variation in CPA pharmacokinetics.
The aim of this thesis...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
Influence of the microflora on gastrointestinal nitric oxide generation : studies in newborn infants and germ-free animals
(2006-05-11)
is still unclear. Denitrifying bacteria in soil generate NO from nitrate (NO 3-) and nitrite (NO 2-) as a part of the nitrogen cycle. In this project we wanted to investigate whether the micro-organisms residing in the gastrointestinal (GI) tract could...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
Background & Aim: Tobacco smoking exerts a harmful effect on the periodontal tissues manifested by periodontal pockets, attachment loss and periodontal bone loss. Current evidences on the effects of tobacco on periodontal ...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
with a more modest increased risk of the disease. Mutations in the known high risk genes BRCA1, BRCA2 and p53 account for less than 25% of the familial risk for breast cancer, while the remainder remain genetically unexplained despite a large effort...
Studies on alcoholic liver disease
(2006-11-17)
of alcohol related liver disease. We found that rats had appearance of IgG against rat CYP3A 1 and CYP2E 1 during chronic ethanol feeding We found that patients had reactivity against CYP3A4 and CYP2E I in about 20 to 30% and 10 to 20% of the alcoholic sera...
Molecular characterization of the Ro52 autoantigen and its disease related epitopes
(2005-01-14)
and functional studies. The RING and B-box together form a single folding unit. Two Zn2+-binding sites with nanomolar affinities were found within the RING-finger, while the B-box contains one independent Zn2+-binding site with micromolar affinity. The region...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins ...
Volume kinetics of glucose solutions given by intravenous infusion
(2005-05-10)
Fluid therapy is often cumbersome to plan since the distribution and the elimination of the administered solution are difficult to analyze in the clinical setting. The knowledge of the adequate rate and dose for each ...
Population structure and antibiotic resistance of the genus enterococcus in humans, animals and the environment
(2005-11-18)
the prevalence of antibiotic resistant enterococci in these samples. In a European study, 17,157 enterococcal isolates from 2,868 samples from humans, animals and the environment in Sweden, Denmark, the United Kingdom, and Spain were studied (study I...