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Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Studies of preoperative evaluation and surgical procedures for gastroesophageal reflux disease
(2006-11-10)
Introduction: Gastroesophageal reflux disease (GERD) is defined as the non-physiological movement of gastric contents from the stomach to the esophagus, which causes various degrees of troublesome symptoms and/or esophageal ...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
Eating habits among adolescents and their mothers : Stockholm Weight Development Study (SWEDES)
(2008-04-04)
The aims of this thesis were threefold. Firstly, to explore the possibility to improve the quality of dietary data and to identify under- and overreporters of energy intake. Secondly, to investigate the eating habits of ...
Adenosine receptors and stress : studies using methylmercury, caffeine and hypoxia
(2008-02-21)
system function may not necessarily be apparent until a critical age when neurodevelopmental defects may be unmasked by a subsequent challenge. Adenosine and its receptors (AR) (A1, A2A, A2B and A3) which participate in the brain stress response...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
, we produced transconjugants from clinical isolates of carbapenem resistant P. aeruginosa in a sensitive PAO18 after selection for a proline marker (proB). The active sites of penicillin-binding proteins PBP1b, PBP2, PBP3 and PBP6 were sequenced...