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Gene regulation and immune mechanisms in multiple sclerosis experimental models
(2007-09-04)
-EAE was exacerbated in mice that lacked TLR4, TLR4 signaling decreased IL-6 and IL-23 production and TLR4-/- mice had a higher frequency of splenic Th17 cells and more sera IL-17. TLR9-/- mice developed more severe MOGEAE and higher IL-17 levels than WT mice...
Strategies to improve outcome after islet transplantation using the GLP-1 receptor agonist, extendin-4
(2007-05-04)
cultured with exendin-4 (0.1 mnol/L) for 20 hours in addition to the recipient treatment. In the short-term study, 63% of exendin-4 treated mice achieved graft function compared to 21% of untreated mice (p = 0.03). In the long-term study, 88% of treated...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Placebo, alcohol and flumazenil provocations : subjective and objective registrations in psychopharmacological experiments
(2007-01-12)
Abuse and dependency of alcohol or drugs is a major problem today, with
severe implications for society as well as for the individual. Treatment
is often characterised by hard work and the road to recovery is (among
other ...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
Evaluation of reverse transcriptase assay for viral load monitoring
(2007-05-17)
Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the ...
Knowledge acquisition in patients with heart disease
(2007-09-07)
The general aim was to evaluate different aspects of the knowledge
acquisition process in patients with heart disease. Three different
education programs were evaluated.
In Paper I 208 patients with systolic heart failure ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Fixed-dose chloroquine and sulfadoxine/pyrimethamine treatment of malaria : outcome and pharmacokinetic aspects
(2007-04-06)
Background: A pre-packaged fixed-dose formulation of chloroquine (CQ) and
sulfadoxine/pyrimethamine (SIP) combination (Homapak) is widely used for
the treatment of falciparum malaria in the Home Based Management of
Fevers ...
Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences
(2007-04-06)
Cortisol is the principal circulating glucocorticoid in man and has a
wide variety of effects in the body. In advanced metastatic cancer,
glucocorticoids are used to alleviate symptoms such as anorexia, poor
strength ...