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p73 : regulator of differentiation and apoptotic cell death
(2007-05-04)
Neoplasia is characterized by cells' loss of self-control due to
deregulated apoptotic and cell proliferation pathways. Anticancer
treatments aim to induce either cell cycle arrest or apoptosis, and these
effects are ...
Gene regulation and immune mechanisms in multiple sclerosis experimental models
(2007-09-04)
) and 10th (G10) generation of an advanced intercross line between susceptible DA and resistant, but MHC identical, PVG.AV1 strains confirmed their influence on MOG-EAE. Very narrow QTL confidence intervals with restricted sets of genes were demonstrated...
On the pro-apoptotic signaling induced by interferon-alpha
(2007-04-06)
Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used
as an active drug in the treatment of malignant diseases for almost five
decades. It has shown beneficial results in several hematological
malignancies, ...
In vitro models to study mechanisms of neural cell death induced by toxic agents
(2007-11-29)
Neurotoxicity arises when exposure to toxic agents, either naturally
occurring or manmade substances, alters the normal activity and/or
structure of the nervous system. This can lead to disruption of vital
metabolic processes ...
Weight loss programmes over the internet : opportunities and limitations
(2007-11-21)
an opportunity to use the Internet for weight
reduction purposes.
Aim: 1. To identify characteristics of individuals seeking help for their weight problem via an Internet-based programme (Paper I); 2. To identify indicators of long term success in such a...
Learning across paradigms : towards an understanding of the development of medical teaching practice
(2007-05-12)
The purpose of this thesis was to investigate how educational developers
can work strategically with change to develop quality in higher education
institutions in general and in medical education in particular. The
thesis ...
Limitations of maximal oxygen uptake during whole-body exercise
(2007-10-26)
were: 1) To
determine and investigate the importance of the work of the heart as a
limiting factor in the attainment of maximal oxygen uptake during maximal
or supramaximal workloads, 2) To elucidate the relationship between
maximal oxygen uptake during...
Newer antiepileptic drugs in women of child-bearing age : pharmacokinetic studies during pregnancy, breastfeeding, and contraception
(2006-11-24)
Epilepsy is a common neurological disorder, affecting men and women almost equally. It has been estimated that 0.3 to 0.4% of pregnant women have epilepsy. Treating women with antiepileptic drugs (AEDs) during pregnancy ...
The road to diagnosis and treatment of patients with lung cancer
(2006-11-27)
Lung cancer is the third most common cancer among men and women in Sweden. More than 3000 persons/year are diagnosed with lung cancer. Despite the presence of many and intense symptoms at diagnosis, most patients still ...
Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat
(2007-05-25)
The aim of the thesis was to investigate the effects of the 5-HT1A
receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor
antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl)
oxymethyl-morpholine methanesulfonate...