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Cyanoacetylation of indoles, pyrroles and amines, and synthetic uses of these products
(2005-02-25)
This thesis is based on an organic synthetic project aimed towards development of small molecules acting on the P2 receptor as well as development of synthetic methods to such molecules (primarily indoles and featuring ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Sarcoplasmic body myopathy
(2005-10-13)
In 1980 a new hereditary myopathy with adult onset was described in a swedish family. The most characteristic feature of this myopathy was the sarcoplasmic inclusion bodies (SB), seen in the muscle biopsies. Distal muscle ...
Individualized leukapheresis of hematopoietic cells for cellular therapies
(2005-11-24)
Hematopoietic stem and progenitor cells from blood (HSC) are collected by leukapheresis from patients after mobilization with G-CSF +/- chemotherapy to be used in autologous transplantation. The established method to measure ...
Quantitative EEG analysis : temporal variability and clinical applications
(2005-09-30)
) for the power of 4 s epochs was in the range 0.49-0.67 (delta), 0.53-0.58 (theta), 0.58-0.76 (alpha), 0.37-0.49 (beta) and 0.09-0.12 for die alpha peak frequency. CV decreased proportionally to the square root of the sample size. Increasing the recording length...
Diet and ovarian cancer : a population-based cohort of 60 000 women
(2005-05-06)
.
Dietary folate intake was inversely related to the risk of ovarian
cancer. Compared with women in the lowest quintile (<150 μ g/day) of
dietary folate intake, the multivariate RR for those in the highest
quintile ( ³ 212 μ g/day) was 0.50 (95% CI, 0.31-0...
Infant feeding and allergy in children
(2005-11-04)
and 4 years to collect information on exposures and health outcomes. The response rate at 4 years was 91%. Among these children a clinical investigation was performed in 73%, which included peak flow measurement and blood sampling for analysis...
Opioids and regulation of breathing
(2004-10-29)
, and frakefamide, a peripherally active µ-opioid receptor agonist. The general aim of these studies was to extensively examine if these drugs depress ventilation.
In study I, we investigated the effects on resting ventilation of two doses of sameridine 0.15 mg...
Nitric oxide : a surrogate marker of bowel inflammation
(2005-10-28)
% and specificity of 91 % in discriminating between IBS and active IBD. Rectal levels of NO were correlated to disease activity in patients with IBD or CC and were reduced markedly in IBD patients who responded to treatment. Surprisingly, rectal levels of NO were...
Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(2005-11-24)
. The second part concentrates on the palladium-(0)catalyzed cross-coupling reactions of 4- and 5-substituted 2,1,3-benzoselenadiazoles.
The heterocyclic amines described can be divided into the linear and the angular compounds. Five linear imidazo[4,5-b...