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Native protein mass spectrometry of nuclear receptor-ligand and enzyme-substrate complexes
(2004-11-05)
Nuclear receptors (NRs) are transcription factors that are activated by the binding of low molecular weight ligands. The NR superfamily includes receptors for steroid hormones, anti-inflammatory and lipid-lowering drugs ...
T cell responses and NK cell function in experimental autoimmune diabetes
(2004-11-12)
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent autoimmune diseases. However, genetic as well as environmental factors can increase the risk of breaking self tolerance. ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Genetic dissection of experimental arthritis in the DA rat
(2005-01-28)
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting peripheral joints. Persistent inflammation causes cartilage deterioration with severe joint deformations as a consequence. The etiology is largely unknown ...
Modeling the economics of prevention
(2005-04-29)
Cardiovascular disease, particularly coronary heart disease and stroke, is the most common cause of death world wide, with a prevalence that is expected to increase. The consequences of the modern lifestyle such as obesity ...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...
Matrix metalloproteases and cell motility in malignant mesothelioma
(2004-10-29)
in malignant mesothelioma cells. All investigated mesothelioma cell lines expressed mRNA for MMP-1, MMP-2, MMP-3, MMP-9 and 6/8 cell lines expressed MMP-7, 3/8 cell lines expressed MMP-10. MMP-11 was not detected in any of mesothelioma cell lines tested. MMP-2...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
Overweight prevalences are rising among youth and the prevention of associated chronic diseases is priority concern in public health. Inflammatory processes are involved in the pathogenesis of cardiovascular diseases and ...
Particularly harmful particles? A study of airborne particles with a focus on genotoxicity and oxidative stress
(2006-11-22)
Today it is well established that particulate matter (PM) cause a wide range of health effects. The underlying mechanisms likely include inflammation, oxidative stress and genotoxicity. There is however a lack of knowledge ...
Psychsocial consequences of high and intermediate imperforate anus
(2005-10-21)
Imperforate anus including lack of a normal anorectum is an uncommon malformation. The parents of children born with high and intermediate imperforate anus have to take a big responsibility for the follow-up treatment. It ...