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Adaptive responses during giardia-host interactions
(2005-01-28)
Giardia lamblia is a major cause of water-borne enteric disease. The parasite is a noninvasive, flagellated protozoan that inhabits the upper part of the small intestine of its vertebrate hosts. Differentiation is central ...
The type-I acyl-CoA thioesterase/acyltransferase gene family : linking structure to function
(2005-05-27)
Acyl-CoA thioesterases hydrolyse acyl-CoAs to non-esterified fatty acids and coenzyme A (CoASH), thereby regulating intracellular levels of these compounds. We have recently identified and initiated characterisation of a ...
Serodiagnosis and seroprevalence of Helicobacter pylori infection in Vietnam
(2006-10-19)
disease (PUD), gastric biopsies and serum samples were obtained from 296 PUD patients (age 18-88 years). H. pylori status was confirmed by culture and/or serology at inclusion, after treatment and after 12 (+/-2) months of follow-up. Serum samples from 91...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
and microsomal activity were reached at 4-8 hours after the dose. The induction in mRNA, protien and the enzyme activity were dose dependent. These results demonstrate that CPA has a high inducing effect on CYP2B1 and 2B2 in rat.
In multiple dose schedule...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
Background: Diabetes mellitus (DM) and impaired glucose tolerance test
(IGT) are well known risk factors for cardiovascular disease (CVD).
Individuals with IGT, a prediabetic state, are asymptomatic during many
years ...
Studies on growth hormone induced female-characteristic gene transcription in rat liver
(2005-05-06)
Growth hormone (GH) secretion is sexually dimorphic, which has an impact on hepatic gene expression. This is particularly pronounced in rats but has also been demonstrated in other species, including humans. The male GH ...
Targeting insulin-like growth factor-1 receptor in cancer
(2004-09-24)
Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. The synthesis of barettin and 8,9dihydrobarettin was performed in this work, involving a highly functionalised arginine derivative. This arginine derivative was used in a peptide...
Organic dust-induced signaling in human pulmonary epithelial cells : emphasis on effects of cAMP modulation
(2005-09-09)
signal in inflammation and an additional aim was to iiii) elucidate effects of increased cAMP on expression of the pro-inflammatory cytokines interleukin (IL)-6, IL-8, TNF and the TNF receptors, R1 and R2 using 8-bromo-cAMP and the PKA-inhibitor, H-89...
Characterization of cochlear degeneration in the inner ear of the German waltzing guinea pig : a morphological, cellular, and molecular study
(2006-11-03)
The German waltzing guinea pig is a new strain of animals with yet unknown gene mutation(s) displaying recessively inherited cochleovestibular impairment. The homozygous animals (gw/gw) are deaf already at birth and display ...