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Aspects on the etiology of esophageal and gastric cancer
(2004-11-12)
completeness of the Cancer Register of 98.3%, while the site-specific accuracy was only 63% for esophageal adenocarcinoma, 74% for gastric cardia adenocarcinoma, and 91% for esophageal squamous-cell carcinoma. The increasing incidence rate of esophageal...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
Accumulating evidence suggests that hyperinsulinemia, in the context of insulin resistance, is associated with carcinogenesis. Physical activity is involved in the regulation of metabolic and hormonal pathways and is an ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Glucose regulation and coronary artery disease : studies on prevalence, recognition and prognostic implications
(2005-05-20)
). The probability of remaining free from cardiovascular events was significantly lower in patients with abnormal than those with normal glucose tolerance (p=0.002). Abnormal glucose tolerance (hazard ratio 4.18, 95% Cl 1.26-13.84, p=0.019) and prior myocardial...
Outcome of an 8-week multiprofessional work-related rehabilitation programme for patients suffering from persistent musculoskeletal-related pain
(2006-11-24)
at an individual level but it was possible at group level. At the 3-year follow up 50 % of the patients were working and at the 6-year follow up 52% had returned to work (p <0.001). In the control group 13 % had returned to work (p <0.001). There was a...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Dietary and genetic factors in the etiology of prostate cancer
(2006-05-19)
The etiology of prostate cancer is poorly understood. However, genetic factors may be more important than for many other malignancies. In addition, several studies suggest that dietary factors axe of etiologic importance. ...
The human skeletal muscle in vivo : the use of microdialysis to study glucose metabolism and insulin resistance
(2004-11-26)
The aim of this thesis was to further develop the microdialysis technique for studies of glucose metabolism and insulin resistance in human skeletal muscle in vivo and to use this technique to explore the effect of exercise ...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results
(2006-02-17)
that glucuronide conjugation of ethanol forming EtG represents a minor elimination pathway (<0.03%) in the human body, and also confirmed that EtG remains detectable in the urine for many hours after the ethanol has been eliminated. Drinking large amount of fluid...