Search
Now showing items 1-10 of 40
Estrogen effects on different neurotransmitters in rat hippocampus : implications for cognitive function
(2004-11-12)
The past decade has witnessed a growing interest in estrogens and their
activity in the central nervous system, which extends beyond the
reproductive functions. Estrogen is known to interact with different
neurotransmitter ...
On mapping the human somatosensory cortex : fMRI and PET imaging
(2004-08-26)
the BOLD response in 10 subjects whilst passively discriminating various parallelepiped objects presented to their right hand or foot. Separate representations of hand and foot activations should represent somatotopical organisation. Areas 3a, OP2 and OP3...
Aldehyde toxicity in human oral epithelium
(2004-11-19)
of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity...
Molecular aspects of proinsulin C-peptide interactions
(2006-05-10)
-signal regulated kinase (ERK) 1/2 correlates with the presence of residues Glu-3, -11 and -27 as well as non-helix-breaking residues in the N-terminal third of C-peptide, which forms a helical structure in trifluoroethanol. A tripartite model of C-peptide activity...
Sleepiness : night work, time zones and activity
(2006-05-26)
Shift work and travel across time zones affect sleep and alertness negatively, and hence influence accident rate. Self-selected work hours, contextual, and environmental factors affect sleepiness, but it is unclear exactly ...
The use of the world wide web in epidemiological research
(2006-10-06)
The world is becoming smaller. Through technical innovations all kind of communication is simplified, people come closer, and borders are erased. The Internet plays a major part in this process not only through the ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
and GLP-1 on gastric emptying, metabolic control and appetite after intake of a mixed meal in man. In addition, I (3) studied the effects of ghrelin on smooth muscle contractility in rat and (4) its effect on gastric emptying in humans after intake of a...
Effects of gonadal hormone deficiency on bone mineral density : can physical activity increase bone mineral density in women?
(2006-08-11)
Osteoporosis with its associated fragility fractures is a global health care problem. The incidence of ftagility ftactures has increased dramatically the last 50 years. This has been suggested to at least in part be due ...
Differential RNA expression in benign and malignant adrenocortical tumours
(2005-11-21)
-like growth factor related genes (IGF2, IGF2R, IGFBP3 and IGFBP6). Among other genes that were downregulated in carcinomas were several genes related to cell metabolism (ALDH1A1, RARRES2, CYBRD1 and GSTA4), a cytokine (CXCL 10) and a cadherin 2 (CDH2). Through...
Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein
(2006-05-12)
. It was also found that the apoptosis provoked by SecTRAPs required both caspase-2 and caspase-3/7 activation but not induction of protein synthesis. Either human or rat SecTRAPs could induce apoptosis in human A549 (lung adenocarcinoma) or HeLa (cervix...