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Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation
(2006-05-19)
, containing plenty of cholesterol crystals. In addition they had elevated levels of hepatic Abcg5/g8 mRNA. These effects were all absent in the Cyp8bl -/- mice or in +/+ animals treated only with alloxan.
Our results indicate a crucial role of Cyp8b1/CA...
Incidence and prognosis of differentiated thyroid cancer in Sweden
(2006-01-06)
Non-medullary differentiated thyroid cancer (DTC) is a rare disorder but, nevertheless, among the most common cancers in individuals below 40 years of age. DTC consists of papillary (PTC) and follicular (FTC) thyroid cancer. ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Antibacterial effects of nitrite in urine
(2005-04-01)
Urinary tract infections (UTI`s) are among the most common conditions causing individuals to seek medical care. In addition, catheter-associated infections account for most of the hospital-acquired UTI´s and is also a major ...
Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation
(2005-03-18)
Antimicrobial peptides are endogenous antibiotics and effector molecules
of Innate immunity. These peptides are mainly localised to epithelial
linings and circulating neutrophils. They kill microbes by disruption of
their ...
Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
(2006-10-27)
The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several ...
The human skeletal muscle in vivo : the use of microdialysis to study glucose metabolism and insulin resistance
(2004-11-26)
The aim of this thesis was to further develop the microdialysis technique for studies of glucose metabolism and insulin resistance in human skeletal muscle in vivo and to use this technique to explore the effect of exercise ...
Molecular mechanisms regulating exocytosis : studies of insulin secretion and neurotransmitter release
(2005-02-11)
expressed in neurons. Cdk5 was identified in pancreatic ?-cells where it functions as a positive regulator of insulin secretion. Although ?-cells expressed both of the identified Cdk5 regulatory subunits, only Cdk5, activated by p39, enhanced insulin...
In vitro and in vivo studies on biodegradable matrices for autotransplantation
(2006-04-07)
Tissue engineering (TE), one of the most rapidly growing fields of life science, is an interdisciplinary area in which technical, biological and medical expertise co-fertilize on another with the ultimate aim of restoring, ...