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Effect of body posture on regional ventilation and perfusion at normal and increased gravity
(2006-10-20)
supine and redistribution of blood flow is not the primary cause of arterial desaturation at 3 G. Gravity redistributes regional blood flow and ventilation when upright, while the influence is less in the supine and prone postures. Moreover, a change...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
concentration of DMSO can be as high as 5% (v/v), or 715 mM. Our study revealed significant differences in the behaviour of the proteins in the presence and absence of low amounts of DMSO (0.1- 3%). In addition, we showed that low DMSO concentrations influence...
Glucose regulation and coronary artery disease : studies on prevalence, recognition and prognostic implications
(2005-05-20)
). Diabetes was already known in 1524 patients. From 3 437 of the remaining subjects, fasting glycaemia was available in 2 679 while 1 920 underwent an oral glucose tolerance test. Newly detected diabetes was recognised in 22 and 14% of patients with acute...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
and GLP-1 on gastric emptying, metabolic control and appetite after intake of a mixed meal in man. In addition, I (3) studied the effects of ghrelin on smooth muscle contractility in rat and (4) its effect on gastric emptying in humans after intake of a...
Methological advances in the examination of the dopamine system in brain
(2005-11-18)
) examination of the interaction between D2/D3 receptors and G proteins in human brain in vitro, (ii) selective visualization of D3 receptors with PET, and (iii) improvement of the accuracy in PET imaging of D2/D3 receptors by correction for partial volume...
Differential RNA expression in benign and malignant adrenocortical tumours
(2005-11-21)
-like growth factor related genes (IGF2, IGF2R, IGFBP3 and IGFBP6). Among other genes that were downregulated in carcinomas were several genes related to cell metabolism (ALDH1A1, RARRES2, CYBRD1 and GSTA4), a cytokine (CXCL 10) and a cadherin 2 (CDH2). Through...
Activating proto-oncogene mutations in human cutaneous melanoma
(2005-05-13)
Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary melanoma; 4) vertical...
Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids
(2006-10-20)
tubular cells (HRTCs) was determined. Insulin- and C-peptide stimulated Na+,K+-ATPase activation, as assessed by ouabain-sensitive 86Rb+ uptake and 3H-ouabain binding, phosphorylation of α- and translocation of α- and β-subunits to plasma membrane from...
Airway responses to NO2 and allergen in asthmatics
(2005-04-08)
to 500 µg/m3 N02 or purified air for 30 minutes, followed four hours later by an allergen inhalation challenge. Bronchoscopy was performed 19 hours after the allergen challenge. This single 1/2-hour exposure to N02 followed by allergen gave an increase...
Physical activity, body composition and physical self esteem among children and adolescents
(2005-02-25)
The increasing prevalence of overweight and obesity poses a global health problem. Special concern is focused on overweight during youth since it may cause negative impact on health both during childhood, adolescence and ...