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Blue light induced retinal damage
(2004-09-17)
Visual perception results from a response to radiation between 400 and 760 mu reaching the retina. Photoreceptor cells are differentiated post-mitotic retinal neurons uniquely adapted for the efficient capture of photons ...
T cells in atherogenesis
(2004-08-13)
The work of this thesis aims to answer the following questions: (1) Which
role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4
essential for the athero-protective effect mediated by immunization ...
Translational studies of drug-induced tumor cell death
(2006-09-29)
It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ...
Immersion and recreational boating-related injuries in Alaska
(2005-11-04)
Background: Cold water is an ever-present hazard in Alaska, and when water-related injuries occur, they often take place in remote environments, where the nearest trained emergency response teams are several hours away. ...
Infections in patients with haematological malignancies
(2005-10-28)
Infectious complications are an important cause of morbidity and mortality in patients with hematological diseases, especially during chemotherapy induced neutropenia. This study was undertaken with the ultimate goal to ...
Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
(2006-04-07)
One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin ...
Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
(2005-10-07)
The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival ...
Regulation of carbohydrate metabolism in skeletal muscle during and after contraction
(2006-11-03)
It is well known that exercise increases glucose transport into skeletal muscles. The regulation of this transport, however, is poorly understood. An increased understanding of the mechanisms underlying glucose transport ...
Organic dust-induced signaling in human pulmonary epithelial cells : emphasis on effects of cAMP modulation
(2005-09-09)
To study signaling transductions in innate immunity a model system was applied where A549 alveolar epithelial type II cells were used as target and organic dust collected in swine confinement buildings as stimulus. The ...
Pain management in outpatient knee arthroscopy
(2006-04-14)
Knee arthroscopy is probably the most common orthopaedic procedure performed. The objective of this thesis was to compare local anaesthesia with other used anaesthetic techniques for outpatient knee arthroscopy. The choice ...