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Algorithms for building and evaluating multiple sequence alignments
(2006-09-05)
The alignment of biological sequences is crucial for the transfer of annotation from model organisms to humans. Pairwise alignment of sequences can reveal homology while multiple alignments are used to characterize protein ...
Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
Our main goal has been to identify new means to improve chemotherapy of
acute leukaemia:
1. By using low-density lipoprotein (LDL) as a drug carrier to increase
the selectivity of antileukemic drugs, based on high LDL ...
Epidemiology and prevention of home related injuries in the Islamic Republic of Iran
(2005-11-03)
Background: As elsewhere, unintentional injuries are among the leading causes of death In Iran, but non-fatal injuries due to injury events In the home environment have not been analyzed. Many injuries occur in the home ...
Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies
(2004-11-12)
Background: Several epidemiological studies the past fifteen years have
suggested a connection between fetal growth retardation and later effects
on adult health, such as an increased arterial blood pressure and type ...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall ...
Modeling the economics of prevention
(2005-04-29)
Cardiovascular disease, particularly coronary heart disease and stroke, is the most common cause of death world wide, with a prevalence that is expected to increase. The consequences of the modern lifestyle such as obesity ...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
End stage renal disease (ESRD) is a complex multifactorial disorder, where both environmental and genetic factors are contributing to the phenotype. The most common complications seen in ESRD patients are malnutrition, ...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
of 1-4 and 5-9 years of age and for three out of seven geographical regions. Based on the first 100 ICF, recall was acceptable in 90% of the interviews, successful identification of special events in 84%, good recovery of pesticide names, frequency...
Studies on alcoholic liver disease
(2006-11-17)
patients with alcohol dependence without cirrhosis. Women with alcoholic cirrhosis drank 14 009 drinks of alcohol during their lifetime compared to 45 658 drinks consumed by men with alcoholic cirrhosis. Women with alcoholic cirrhosis reported 9 198 drinks...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of ...