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Defense-peptides against mycobacteria
(2005-09-07)
. The postulated membrane-docking part, helix
2-loop-helix 3, of NK-lysin was found to retain or even improve their
antimicrobial activity compared to their parent molecules. It was also
demonstrated that the shorter peptides maintained their activity against
M...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
via DARPP-32 phosphorylation at Thr34). Clozapine had no effect on Ser845, but it produced a long-lasting (¡Ý120 min) decrease in Ser831 phosphorylation. In the basal ganglia, antipsychotics block dopamine D 2 autoreceptors, thereby stimulating...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
The functional role of the lateral olivocochlear system and mechanisms underlying sound condtioning
(2004-10-29)
by upregulating the bcl-2 level in the outer hair cells. A role of bcl-2 as an inducible gene underlying protection against acoustic trauma by sound conditioning is demonstrated.
Sound conditioning is also effective in protecting against a temporary hearing...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
submitted to 1643 patients recorded in the hernia register during 2 consecutive months in 2002. The response rate was 88% (1448 patients). The most common complications recorded were haematoma in 203 (14%) patients, severe pain in 168 (12%) patients...
Studies of lipolysis and neuroendocrine rhythms in cluster headache
(2006-09-08)
Cluster headache (CH) is characterised by excruciating, unilateral headache attacks, which in the episodic form appear in clusters for weeks or even months. The headache attacks are often accompanied by ipsilateral, cranial ...
Factors for successful improvement of Swedish healthcare
(2005-05-13)
initiatives as superior was selected (n=845). The analysis indicated that there are three main underlying factors that characterizing managers perceptions of improvement. These are: 1) difficulties in the use of improvement practices and techniques 2...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
of the beta2-adrenergic receptor (beta2-AR), such as decreased density of beta2-AR on peripheral blood mononuclear cells (PBMC), serum antibodies against beta2-AR and aberrant distribution of SNPs of codon region within the 02-AR gene. I investigated...
Living with hemodialysis therapy
(2004-11-19)
The aim of this thesis was to describe and to characterize patients experiences of suffering from end-stage renal disease. Although suffering is assumed to be an individually experienced phenomenon, the interest was to ...