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Blue light induced retinal damage
(2004-09-17)
of the nucleus, condensation of the cytoplasm, and formation of apoptotic bodies along with rapid removal of dying cells from damaged areas in the absence of inflammatory response. A wave of massive TUNEL labeling of photoreceptor nuclei peaking at 8-16 hours...
The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9
(2004-11-16)
combinations of CYP2C9*1, 2C9*2 and 2C9*3. Overall, the plasma clearance of S-PPC was moderately reduced in CYP2C9 variant allele carriers, while RPPC clearance was essentially unaffected. However, the metabolite formation clearances were impaired in a gene...
Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy
(2004-11-18)
depolarization, activation of caspase-9 and caspase-3,
and an enhanced 1H-MRS lipid/choline ratio. The NSAIDs diclofenac and
celecoxib induced caspase-3 activation in vivo, and significantly
inhibited neuroblastoma xenograft growth.
Supplementing cell lines...
Oral health in old age : perception among elderly persons and medical professionals
(2006-09-29)
The general aim of this thesis was to investigate perceptions of oral health among elderly persons and among medical professionals working at primary health care centres. The study samples consisted of elderly persons and ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
(2006-10-27)
The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several ...
Children's diarrhea in Hanoi, Vietnam : importance of enteric pathogens
(2005-02-18)
Diarrhea is one of the leading causes of illnesses and death among
children in developing countries, where an estimated 1.3 billion episodes
and 4 to 10 million deaths occur each year in children less than 5 years
of ...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
-degrading proteases in the AAA wall. Gene arrays and quantitative real-time PCR showed that matrix metalloproteinase (MMP)-1, -7, -9 and -12 mRNA expressions were upregulated in the thrombus-free wall compared with the thrombus-covered wall. Immunohistochemistry...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
model. We found no association between magnetic field exposure and childhood leukaemia overall. However, elevated risk estimates were found in subgroup analyses of acute lymphoblastic leukaemia in the 5-9 year age group. Random variation is a likely...