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Now showing items 1-10 of 59
The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion
(2004-10-01)
(NO) bioavailability and increased production of endothelin-1 (ET-1). Certain ET-1 receptor antagonists and calcium channels blockers may in addition to their classical actions, affect NO bioavailability.
The aim of the studies was to investigate...
Sleepiness : night work, time zones and activity
(2006-05-26)
obtained with a validated sleep diary in Studies 1 and 11. Study III aimed at investigating subjective sleepiness across and within the four possible watches of the six hours on/six hours off system by using an experimental approach in a bridge simulator...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, due to a natural variation...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
rotation, 2-3 % of neck flexion, and 1.5-2.5 % of trunk inclination. The use of NVG increased muscle activity in upper neck by 0.5-1.5 % and in lower neck by about 0.5 %. Results with added counterweight were about the same as with NVG. Muscle activity...
Development of nuclear medicine methods for gastric and small bowel motility : effects of GLP-1 on gastric emptying
(2005-05-20)
The diagnosis of functional disorders of the gastrointestinal (GI) tract
requires techniques being both sufficiently sensitive to detect
disturbances of the normal physiology and low-invasive enough not to
interfere ...
Dietary and genetic factors in the etiology of prostate cancer
(2006-05-19)
The etiology of prostate cancer is poorly understood. However, genetic factors may be more important than for many other malignancies. In addition, several studies suggest that dietary factors axe of etiologic importance. ...
The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia
(2006-02-22)
from the 5-lipoxygenase metabolism of arachidonic acid, and exerts its action via cell surface receptors denoted BLT1 and BLT2. Our data reveal that SMC express functional BLT1, activation of which induces SMC migration and proliferation, and that up...
Molecular mechanisms of transcriptional repression by the orphan receptor SHP
(2005-02-18)
between SHP and EID1 and identify two repression-defective SHP mutations that have lost the ability to bind EID1. We suggest histone acetyltransferases and histones as targets for EID1 action, and we propose that SHP inhibition of transcription involves...
Gene dose imbalances in children with mental retardation
(2005-01-14)
-CGH). In addition, the performance of CGH on microarrays containing cDNA clones or BAC clones was investigated. From this study, we concluded that the BAC array with an average resolution of approximately 1 Mb is reliable and would add important information...