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Novel non-collagenous modulators of biomineralization in bone and dentin
(2004-11-26)
The formation of mineralized tissues such as bones and teeth is governed on many levels by molecular, genetic, and cellular events to culminate in terminally differentiated cells that secrete a specialized organic matrix, ...
Viral zoonoses in Estonia : hantaviruses and tick-borne encephalitis virus : identification, prevalence, serological and genetic relationships
(2006-02-15)
Hantaviruses and tick-borne encephalitis virus (TBEV) cause serious human infections. Hantaviruses are transmitted to humans by wild rodents and cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary ...
The metabolic syndrome : studies on thrifty genes
(2004-09-25)
The metabolic syndrome consists of a cluster of atherogenic risk factors
that include insulin resistance, glucose intolerance, hyperglycemia,
dyslipidemia, obesity and a procoagulant state with impaired
fibrinolysis. ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. The synthesis of barettin and 8,9dihydrobarettin was performed in this work, involving a highly functionalised arginine derivative. This arginine derivative was used in a peptide...
Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors
(2005-04-01)
Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
Long-term neurodevelopmental outcome after moderate neonatal encephalopathy and after post-term birth : two population-based studies
(2006-03-17)
to children with moderate NE than in the general population (19% vs 8%). Ominous FHR patterns were common in these cases. Fifteen of the 56 children had CP or other major neuroimpairments. Of the 41 without CP, 13 did not participate. Of the 28 children...
Processing, stability and interactions of lung surfactant protein C
(2005-11-23)
Mature SP-C is a 4.2 kDa transmembrane protein which is uniquely expressed in the alveolar type II cell. Human SP-C is generated via multistep proteolytic cleavage of both the C-terminal and Nterminal regions of proSP-C. ...