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Computational exploration of human genome variation
(2004-09-03)
In studies of human genome variation, researchers attempt to identify the DNA sequence differences between our genomes that contribute substantially to variation that can be observed on a physical level (phenotype). Genetic ...
Testosterone treatment in women : aspects on sexuality, well-being and metabolism
(2004-11-05)
The expected postmenopausal lifetime of women in the western world is
about 30 years. Hormones, such as estrogen and progestogen, may affect
the quality of postmenopausal life and have been well studied. Androgens
act ...
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(2006-01-20)
A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for ...
T cells in atherogenesis
(2004-08-13)
The work of this thesis aims to answer the following questions: (1) Which
role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4
essential for the athero-protective effect mediated by immunization ...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
Cigarette smoking is associated with increased prevalence and severity of destructive periodontal disease in terms of periodontal pocketing, periodontal bone loss, and tooth loss. The smoking destructive effect on periodontal ...
Molecular cytogenetic studies of soft tissue sarcoma : with focus on prognosis and acquired events
(2005-03-22)
Soft tissue sarcomas (STSs) constitute a heterogenous group of highly aggressive tumors of mesenchymal origin that account for approximately 1% of all human malignancies. With the aim of eventually improving the diagnostics ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...
Follow-up studies of the obstetrical brachial plexus injury
(2006-09-15)
Aims: The overall aim of these studies were to investigate the influence of different kinds of treatment of the obstetrical brachial plexus lesion, and to study functioning and participation in adolescents with ...
Protein mass spectrometry in the drug discovery process
(2005-04-22)
concentration of DMSO can be as high as 5% (v/v), or 715 mM. Our study revealed significant differences in the behaviour of the proteins in the presence and absence of low amounts of DMSO (0.1- 3%). In addition, we showed that low DMSO concentrations influence...