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Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease
(2006-05-12)
cells over-expressed human APP695, human HTB-15 astrocytes and primary rat astrocytes. Lovastatin treatment induced high expression of alpha nAChRs, activation of MAPK/ERK pathway and an increase of alphaAPPs secretion in these cultured cells...
Magnetic resonance imaging of rectum : diagnostic and therapy related aspects
(2006-03-31)
Papers I-II: The purpose of paper 1 was to assess the size and configuration of the perirectal fatty tissues (PF) using magnetic resonance imaging (MRI). In 25 subjects the volume and cross-sectional parameters based on ...
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(2005-11-18)
The tumor-associated antigen EpCAM (epithelial cell-adhesion molecule) (C017-1A) is over expressed by various human carcinomas, including colorectal carcinoma (CRC). This antigen can be used as a target structure for ...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
the establishment and characterization of transgenic rats expressing human APP695 with the Swedish double mutation (tgAPPswe). These rats were generated by pronuclear injection. using a construct that contained human APPswe cDNA driven by the ubiquitin promoter...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor
(2006-11-23)
Positron emission tomography (PET) has been widely used to study non-invasively function of the brain, pathophysiology of disease and aid in the development of new drugs. PET and selective radiolabeled molecules allow ...
Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease
(2005-11-25)
The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain ...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...
Children with high and intermediate imperforate anus : aspects of care and psychosocial effects of the malformation
(2005-10-21)
The overall aim of this thesis was to investigate the experiences of
children with high and intermediate imperforate anus and of their
parents; how they have experienced care and treatment and what
consequences the ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-chloroacrylonitrile yielded, after expulsion of HCN by refluxing in ethanol, 1-benzyl-4,5,6,7-tetrahydroindole. Formylation and benzylimine formation followed by treatment with TosMIC furnished the desired 2-imidazolyltetrahydroindole....