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On mapping the human somatosensory cortex : fMRI and PET imaging
(2004-08-26)
This work is based on experiments and simulations for the purpose of mapping the human somatosensory cortex. By using a combination of structural mapping (cytoarchitecture), connectivity mapping, functional mapping, and ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Surgical treatment of left main coronary artery stenosis
(2006-04-28)
was used. Additional bypass grafts were inserted in 21 patients (49%). Follow-up at a mean of 45 (range, 7 to 79) months included a stress test, echocardiography, and angiography with intravascular ultrasound of the LMCA.
A total of 552 patients...
Neocortical layer 2/3 microcircuits
(2004-10-13)
Pairs of interconnected neurons form elementary information processing units within neocortical microcircuits. Pyramidal cells within these microcircuits receive synaptic input, both from their connected partners, and from ...
Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid
(2004-08-27)
Three different molecules and three different experimental models were
used to study the migration of molecules in the rat brain: a
neurotransmitter- dopamine, an extracellular market- mannitol, and a
neuropeptide ...
On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system
(2004-11-26)
Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die ...
Neuropeptides, sensory neurons and pain modulation
(2005-08-26)
In the present thesis work we have analyzed the expression, regulation and function of two neuropeptides: galanin and neuropeptide tyrosine (NPY). Their associated receptors, galanin receptor-1 and -2 (GaIR1, -R2) and NPY ...
Multimethodological imaging studies of pathophysiological mechanisms in human epilepsy
(2006-08-11)
Although the pathophysiological mechanisms of human epilepsy are extensively investigated, many questions remain unanswered. One is whether idiopathic generalized epilepsies (IGE) have anatomical substrates. Another is if ...
Fusion activation in murine leukemia virus
(2006-04-21)
This thesis describes the fusion activation in Murine leukaemia virus (MLV). During entry of retroviruses into uninfected cells, the viral and cellular membranes fuse. The fusion process is mediated by the viral envelope ...
Early detection of Alzheimer's disease and dementia in the general population : results from the Kungsholmen project
(2004-09-08)
exhibited impairment on all 3 measures.
In Study IV, the occurrence and predictivity for dementia of 7 syndromes
of cognitive impairment were examined, including previously proposed
criteria for Mild Cognitive Impairment (MCI) subtypes, and modified...