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Analysis and manipulation of autoreactive and tumor-specific T cell responses
(2004-11-29)
subtle and transient oligoclonal expansion of TCRVbeta5.1-Jbeta1.5, TCRVbeta5.1-Jbeta1.3, TCRVbeta5.2Jbeta1.5 and TCRVbeta5.2-Jbeta1.6 in the PLN in comparison to the inguinal lymph node (ILN). Targeting those specific TCR species may offer novel...
Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae
(2006-04-07)
A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA ...
AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
(2005-08-30)
Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like
lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera
which is found in four different clinico-epidemiological forms as Classic
KS ...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
) and C-reactive protein (CRP) are highly elevated in ESRD patients and predict mortality in both healthy and uremic individuals. Hence putative SNPs that may regulate plasma levels of these proteins were investigated (IL-6 SNPs: -597G/A, -174G/C, 5014A...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
oscillations generated by muscle phosphofructokinase (PFK-M) was examined. According to this model, islet PFK-M experiences periodic bursts in activity via autocatalytic activation by its product, fructose 1,6-bisphosphate (F16BP). Primary pancreatic beta...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
Influence of the microflora on gastrointestinal nitric oxide generation : studies in newborn infants and germ-free animals
(2006-05-11)
Interactions between intestinal bacteria and the host play an important role in physiological regulation of gut function and in development of various diseases. Nitric oxide (NO) exhibits a variety of biological actions ...
Antibacterial effects of nitrite in urine
(2005-04-01)
Urinary tract infections (UTI`s) are among the most common conditions causing individuals to seek medical care. In addition, catheter-associated infections account for most of the hospital-acquired UTI´s and is also a major ...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
Background: Leukemias are the most common childhood cancers, accounting for 25-35% of the incidence of all childhood cancer in most populations. In early reports on cancer, Costa Rica ranks among the highest incidence of ...
Advanced radiological imaging in patients treated with Extracorporeal Memebrane Oxygenation
(2006-11-17)
Extracorporeal membrane oxygenation (ECMO) is the use of a modified heart-lung machine to support life during severe acute cardiac and/or respiratory failure. Patients on ECMO are at high risk for complications due to the ...