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Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
harbouring the 670/671 APP Swedish mutation (APPswe), transgenic mice that overexpress human acetylcholinesterase in the brain (hAChE-Tg) and double transgenic mice generated by crossing the two mouse strains (hAChE-Tg//APPswe). The overall aim...
Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease
(2006-04-06)
carrying the Swedish APP 670/671 mutation (APPswe) and sporadic AD. Significant increases of astrocytes expressing the alpha7 nAChR subunits, along with significant decreases in the levels of alpha7 and alpha4 nAChR subunits on neurons, were detected...
Effect of body posture on regional ventilation and perfusion at normal and increased gravity
(2006-10-20)
The prone position is increasingly used to improve arterial oxygenation in intensive care patients with severe acute respiratory failure. This beneficial response is well documented but our understanding of the responsible ...
Haemostatic changes in plasma for transfusion during preparation and storage
(2006-10-30)
of factor VIII other coagulation factors and their inhibitors in blood drawn into half-strength citrate CPD (0.5CPD) and kept at room temperature for eight hours before component preparation. We found no activation of the contact system or coagulation, but a...
Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease
(2005-11-25)
transgenic mice. Subchronic treatment (10 days) with nicotine (0.45 mg/kg/day x 2) reduced the insoluble API-40 and API-42 levels by 46 % and 66 % respectively, while the intracellular Abeta levels remained unchanged. This also resulted in less GFAP (glial...
Muscle protein synthesis : effects of metabolic stress and feeding
(2005-04-29)
is only marginally effective on muscle protein synthesis in ICU patients. To evaluate if a large enough dose of intravenous glutamine supplementation would influence muscle protein synthesis, ICU patients were randomized to receive 0, 20, 40 or 60 g...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Uveal melanoma : epidemiological and clinical aspects
(2005-09-23)
diagnosed with uveal melanoma. The age-standardized incidence rate of uveal melanoma declined significantly among men from 11.7 cases/million to 8.4 cases/million (p=0.002) and was stable in females, 10.3 cases/million to 8.7 cases/million (p=0...
Physical fitness and overweight in Swedish youths
(2005-03-22)
obese. The total prevalence accordingly being 20.1% (95% CI: 18.3% to 22.0%). This sample proved to be heterogeneous concerning overweight status. When obesity and overweight were combined the highest prevalence (26.6%, 95% CI: 21.2 to 32.7) was found...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived ...