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Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
from the first study was used, but underestimated the ribavirin dose. After dose adjustments a mean dose was 2540 mg/day. Due to anaemia, 2 patients required blood transfusions, twice. 9 patients completed treatment and 9 patients were cured...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein ...
Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
(2004-10-29)
locomotion decreases the burst frequency and produces long-lasting oscillations of the intracellular Ca2+ concentration. These oscillations are mediated through PLC and Ca2+ release from internal stores. Furthermore, they are also dependent on Ca2+ influx...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. haloperidol, reduce...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
times lower than that for 18-week-old rats (study I). Rats aged 18 to 60 weeks had a stable MTD of approximately 5 kJ/m2 (study II). The data from rats aged 3 to 60 weeks were used to derive a general expression for threshold dose (MTD) as a function...
Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors
(2005-04-01)
Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule ...
Studies of lipolysis and neuroendocrine rhythms in cluster headache
(2006-09-08)
Cluster headache (CH) is characterised by excruciating, unilateral headache attacks, which in the episodic form appear in clusters for weeks or even months. The headache attacks are often accompanied by ipsilateral, cranial ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...