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Molecular basis of estrogen receptor antagonism
(2006-01-27)
Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined ...
Pain management in outpatient knee arthroscopy
(2006-04-14)
Knee arthroscopy is probably the most common orthopaedic procedure performed. The objective of this thesis was to compare local anaesthesia with other used anaesthetic techniques for outpatient knee arthroscopy. The choice ...
Learning to be a physiotherapist
(2006-05-12)
Few studies have explored student experience of learning in physiotherapy and none has explored student experience throughout an education programme from a student perspective. The traditional role of physiotherapists as ...
Female and male infertility in Nigeria : studies on the epidemiology of infertility in Nigeria with special reference to the role of genital tract infections and sexual and reproductive risk factors
(2005-05-05)
Background: Infertility is a major public health problem in Nigeria,
contributing to inappropriate contraceptive behavior and poor sexual and
reproductive health of women. To date, there is a paucity of scientific
information ...
Capsulotomy in anxiety disorders
(2006-05-26)
mean of 13 years. Main diagnoses were Generalized Anxiety Disorder (n=13), Panic Disorder (n=8) and Social Phobia (n=5). Mean Brief Scale of Anxiety score dropped significantly from preoperative 22 to 10 at long-term. Seven patients had postoperative...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-chloroacrylonitrile yielded, after expulsion of HCN by refluxing in ethanol, 1-benzyl-4,5,6,7-tetrahydroindole. Formylation and benzylimine formation followed by treatment with TosMIC furnished the desired 2-imidazolyltetrahydroindole....
Genetic epidemiological studies of adverse pregnancy outcomes and the role of schizophrenia
(2006-02-24)
The purposes of this thesis were to investigate the importance of genetic and environmental factors in the development of adverse pregnancy outcomes and to investigate the role of schizophrenia as a risk factor for and a ...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived ...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
proteolysis up to 5 hours post-infusion as compared to saline infusion. This finding is important if we should target the mechanisms resulting in changes in the IGF-system during inflammation. However, we cannot exclude that higher levels of IL6 (>0.1 ng/ ml...
Physical fitness and overweight in Swedish youths
(2005-03-22)
in 10-year-old girls and the lowest (17.5%, 95% CI: 13.6 to 22.2) in 16-year-old girls. The prevalence in 2001 was nearly 2.5 times higher, compared to the 1987-sample. Girls attending schools in smaller towns or on the countryside had a nearly two...