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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
(2005-09-09)
with or without walking aids, 35 % reported decreased walking ability, 27 % had never been able to walk, and 9 % had stopped walking.
Study II: Ten children with CP participated in a study comparing two different kinds of walkers (anterior and posterior...
Neutropenic fever during treatment of hematological malignancy : etiology and diagnostics
(2005-01-07)
Fever is the principal and sometimes the only manifestation of serious infection in the neutropenic patient because signs of inflammation may be minimal or absent in this group of patients. The aim of this thesis was to ...
Regulation of gene and protein expression : two model systems
(2005-11-25)
with host Cyclin T1 (CycT1):Cyclindependent kinase 9 (CDK9) proteins cooperatively binding the trans-activation response (TAR) RNA hairpin elements, resulting in phosphorylation of RNA polymerase II and productive elongation of transcription. Tat is the only...
Dietary supplements : trends, demographics and mortality among users
(2004-11-05)
Dietary supplements have received growing attention in society and sales
numbers indicate increased use. Still, time trends in prevalence of users
have been unknown. In order to accurately explore associations between
diet ...
Effect of body posture on regional ventilation and perfusion at normal and increased gravity
(2006-10-20)
The prone position is increasingly used to improve arterial oxygenation in intensive care patients with severe acute respiratory failure. This beneficial response is well documented but our understanding of the responsible ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9...