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Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat
(2005-02-25)
Purple acid phosphatase (PAP) is an iron-containing binuclear acid metallohydrolase with a characteristic purple colour, also referred to as tartrate-resistant acid phosphatase (TRAP), uteroferrin or type 5 acid phosphatase. PAP is highly expressed...
The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms
(2006-02-03)
Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding ...
Characterisation of psoriasis lesions by protein expression profiling
(2006-05-26)
Psoriasis is a common inflammatory skin disease affecting approximately 2% of the population in Sweden. Psoriasis displays clinical heterogeneity leading to several different types of manifestations, among them chronic ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
Fragmentation of elastin, loss of smooth muscle cells (SMCs) and accumulation of inflammatory cells are the histological landmarks of abdominal aortic aneurysm (AAA). In larger aneurysms, an intraluminal thrombus is almost ...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...
Familial risks for cancer with reference to lung cancer
(2004-10-15)
was 1.87 (95% CI 1.66-2.10) for all offspring (0 66 years old) when parents had lung cancer. The proportion of familial affect was 6.39%, and the population-attributable risk of all lung cancers was 2.97%. Lung cancer in offspring was associated...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
of total physical activity to the lowest one were 0.80 (95% CI 0.541.18); 0.87 (95% CI 0.59-1.28); 0.79 (95% CI 0.53-1.17) respectively. High leisure time inactivity (watching TV/sitting 5 hours or more a day) compared to low was associated with increased...
Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors
(2005-04-01)
Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule ...