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Sentinel node biopsy in breast cancer : aspects on validation, diagnostics and lymphatic drainage pattern
(2006-10-06)
with prior intervention were included. The detection rates were 95.3% (710/745) and 90.7% (78/86), respectively. During the follow-up time of almost 2 years, no axillary relapse was found among the 103 patients with a positive SLN that was followed by ALND...
Neurogenesis, neural stem cells and nitric oxide in neuroinflammation
(2005-09-23)
We investigated whether nitric oxide (NO) is produced in MS patients, determining the concentrations of its oxidation products (NOx) in CSF. The total levels of NOx in CSF were significantly increased in all MS groups as ...
Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors
(2006-08-21)
Natural Killer (NK) cells constitute a subset of lymphocytes capable of cytokine production and/or cellular cytotoxicity. Although NK cells can be activated experimentally by a multitude of agents, the in vivo mechanisms ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha ...
Cognitive functions in depression and anxiety disorders : findings from a population-based study
(2006-11-10)
This doctorial thesis examines cognitive functions in depression and anxiety disorders in a populationbased sample that includes mostly untreated persons. It is well established that depression is associated with cognitive ...
Assessment of anti-diabetic effect of Vietnamese herbal drugs
(2005-11-18)
stimulated insulin release at 3.3 and 16.7 mM glucose from isolated rat pancreatic islets of both W and GK rats. Interestingly, B- cell sensitivity to phanoside is higher at 16.7 mM than at 3.3 mM glucose, since significant insulin responses were observed...
Studies on alcoholic liver disease
(2006-11-17)
The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of ...
Human salmonellosis : impact of travel and trade from a Swedish perspective
(2006-09-08)
Background: Salmonellosis is one of the most important gastrointestinal infections in humans. The vast majority of Swedish Salmonella cases have acquired the disease abroad, reflecting both a large number of Swedish ...
Coordination of endocytosis at the synaptic periactive zone
(2006-03-03)
Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To ...