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Functional studies of the multiple endocrine neoplasia type 1 gene
(2004-10-22)
The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is
an autosomal dominant trait with a near 100% penetrance and with an
estimated prevalence of 2-20/100 000. The syndrome is characterized by
neoplasia ...
Regulation of insulin-like growth factor-II in human liver
(2006-09-02)
Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Genetic and molecular determinants in inflammatory bowel disease
(2006-11-21)
), known to be a recognition receptor for bacteria, could be a putative candidate gene in IBD. While the ΔF508 CFTR heterozygosity is markedly underrepresented in Crohn Ls disease patients from Italy and Sweden, stratification for disease location revealed...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Depression and suicidal behavior in Uganda : validating the response inventory for stressful life events (RISLE)
(2005-05-11)
Background: Depression and suicide ideation are prevalent in the general
population but their recognition and detection in primary care is
problematic. The present study investigated if the RISLE can be used to
detect ...
Anxiety, exhaustion and depression in relation to periodontal diseases
(2006-03-10)
level in GCF was increased, whereas the patients in Study IV surprisingly showed lower cortisol values in GCF than the controls. The level of cortisol in saliva was similar in both groups. Neither did the levels of matrix metalloproteinases-8, -9 (MMP-8...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
Cigarette smoking is associated with increased prevalence and severity of destructive periodontal disease in terms of periodontal pocketing, periodontal bone loss, and tooth loss. The smoking destructive effect on periodontal ...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...