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The influence of psychosocial stress, socioeconomic differences and coffee consumption in the etiology of type 2 diabetes
(2004-12-24)
Type 2 diabetes is a chronic disease of multiple etiology and with increased prevalence during the past two decades. We investigated the influence of psychosocial stress in association with type 2 diabetes and looked further into possible...
The impact of estrogens on leukocyte function in remodeling of extracellular matrix
(2005-11-23)
enzymes, capable of degrading components of connective tissue. Cervical leukocytes were identified as a source of matrix metalloproteinase-2 and 9, which have collagen IV and proteoglycans as substrates. An increased level of these enzymes in the cervix...
Functional domains in the Alzheimer's disease-associated presenilin 1 protein
(2004-10-29)
presenilin (PS), nicastrin (Net), Aph-1 and Pen-2. The
gamma-secretase complex is an unusual transmembrane aspartyl protease
that cleaves APP within the transmembrane domain. Two aspartate residues
within transmembrane regions of the multispanning PS protein...
alpha-Melanocyte-stimulating hormone in neurodegenerative processes
(2006-01-20)
neurodegeneration in rats (1) global cerebral ischemia, and (2) administration of the excitotoxic amino acid kainic acid (KA), a commonly used model of human temporal lobe epilepsy. An important event in both of these models is excessive glutamate receptor...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Effect of body posture on regional ventilation and perfusion at normal and increased gravity
(2006-10-20)
The prone position is increasingly used to improve arterial oxygenation in intensive care patients with severe acute respiratory failure. This beneficial response is well documented but our understanding of the responsible ...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through...
Assessment of anti-diabetic effect of Vietnamese herbal drugs
(2005-11-18)
The prevalence of type 2 diabetes mellitus is increasing in Vietnam as well as in other developing countries (China, Indian subcontinent, and Africa). Searching for hypoglycemic agents with origin from domestic herbals was considered as a useful way...
Pain and physical activity in rheumatoid arthritis : a cognitive approach in physical therapy
(2005-05-06)
-C); and two cross-sectional studies on relations between pain and physical activity on the one hand, and health locus of control, beliefs about relationships between pain and impairment, and fear-avoidance, on the other. A total of 585 patients with RA were...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...