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Prenatal diagnosis in routine antenatal care : a randomised controlled trial
(2005-11-04)
-week group (0.5/1,000 vs. 0.8/1,000, n.s.). For every case of DS prenatally detected, 38 and 85 amniocenteses were performed. Excluding testing for reasons other than those defined in the study protocol, the corresponding figures were 16 and 89...
The impact of estrogens on leukocyte function in remodeling of extracellular matrix
(2005-11-23)
Background: Major reproductive events such as menstruation, ovulation, implantation and cervical ripening are characterized by an increased number of invading leukocytes in the tissues. Sex steroid hormones, particularly ...
Molecular aspects of proinsulin C-peptide interactions
(2006-05-10)
Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (C-peptide), ...
On the genetic variation of interleukin-6 in health and coronary heart disease
(2005-03-18)
There is increasing evidence that inflammation plays an important role in the development of atherosclerosis and coronary heart disease (CHD). Prospective studies on healthy individuals and on patients with unstable angina ...
Women’s experiences of fetal screening for Down’s syndrome by means of an early ultrasound examination
(2005-03-25)
The general aim of this thesis was to explore women’s reactions to and experiences of fetal screening for Down’s syndrome (DS) by means of an ultrasound examination, including measurement of fetal nuchal translucency (NT). ...
Development of a vaccine against strangles
(2005-09-16)
Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical ...
Molecular studies of complications in end stage renal disease : focus on expression and variations of candidate susceptibility genes
(2005-09-09)
End stage renal disease (ESRD) is a complex multifactorial disorder, where both environmental and genetic factors are contributing to the phenotype. The most common complications seen in ESRD patients are malnutrition, ...
Chronic infection with chlamydia pneumoniae in COPD and lung cancer
(2005-09-16)
Lung cancer and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality throughout the world. Smoking is the main cause for both diseases, but other factors seem to contribute. Chlamydia ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Studies on alcoholic liver disease
(2006-11-17)
The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of ...