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Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
the resistant sublines expressing Pgp,
K562/Vcr and/Dnr.
2. By studying the relation between DNR concentration and apoptosis
induction in leukemic cells. We studied the time course of induction of
apoptosis by DNR in HL60 and K562 cells and in isolated...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer
(2005-11-18)
anti-tumour activity of human ex vivo expanded NK cells were evaluated against human K562 cells in SCID-beige mice (Paper IV). Mice treated with expanded NK cells had significantly prolonged survival compared to the untreated group. Finally, NK and NKT...
Pharmacological and clinical studies of new ways to improve cytostatic treatment of acute myelocytic leukemia : in vitro and in vivo studies
(2005-02-18)
of the drug in resistant cells, probably via the P-gp. This was confirmed, as the sensitivity to Ara-C was increased in combination with reversing agents CsA and PSC, measured by cytotoxicity, DNA fragmentation and caspase-3-like activity. Likewise, in K 562...
Flow cytometric methods for assessment of cell-mediated immune responses
(2005-05-27)
responses has been based on the use of complex, labourintensive, and less informative bulkresults assays (51Cr-release, 3 3H-thymidin uptake and Limiting dilution assay, LDA). Alternative techniques for assessment have been developed (tetramer...
Modeling the economics of prevention
(2005-04-29)
Cardiovascular disease, particularly coronary heart disease and stroke, is the most common cause of death world wide, with a prevalence that is expected to increase. The consequences of the modern lifestyle such as obesity ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. Enhanced expression of MMPs including MMP-1 and MMP-3 is demonstrated in gingival connective tissue of individuals with periodontal...
Peptic ulcer disease in an adult population : the Kalixanda study – a population-based endoscopic study
(2006-12-21)
Introduction: The pattern of symptoms and perception of disease among
patients seeking care does, due to health care seeking behaviour, most
probably not reflect the true health status in the general population.
Upper ...
Physical fitness and overweight in Swedish youths
(2005-03-22)
obese. The total prevalence accordingly being 20.1% (95% CI: 18.3% to 22.0%). This sample proved to be heterogeneous concerning overweight status. When obesity and overweight were combined the highest prevalence (26.6%, 95% CI: 21.2 to 32.7) was found...