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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Molecular studies of Neisseria : host cell interactions
(2004-08-11)
of the epithelial barrier. A correlation between neisserial pathogenesis and deficiencies in complement factors has been observed.
To investigate novel interactions between regulators of the complement system and Neisseria we focused on C4b-binding protein (C4BP...
Rotavirus in pediatric gastroenteritis in Nicaraguan children
(2004-10-26)
, collected during 2001 to 2003, rotavirus strains of
serotype G1 P[8] were the predominant, followed by G2 P[4] and G3 P[8],
G4 P[6] and 4% were uncommon strains. A shift for G types was observed;
genotype G2 was the most prevalent during 2001 (70...
Adaptive responses during giardia-host interactions
(2005-01-28)
.
During vegetative growth of the binucleated trophozoites, each nucleus cycle between a diploid (2N) and tetraploid (4N) genome content. Fully differentiated cysts contain four nuclei, each with a ploidy of 4N, resulting in a cyst ploidy of 16N. The newly...
Giardiasis in Leon, Nicaragua : prevalence and protection
(2006-11-20)
(ADI) ornithine carbamoyl transferase (OCT), and VSP4EX. All tested milk samples reacted with the recombinant antigens.
Specific reactivity of milk antibodies with the ventral flagellae of the parasite was observed. Milk antibodies showed a similar...
Novel signaling pathways : induced by bacterial toxins in eukaryotic cells
(2005-09-23)
Inflammation is the process by which the host counteracts microbes that are constantly exposing the human body. These microbes rarely cause disease, due to the effective defense mechanisms of the host immune system. Although ...
Identification of new proteins and biological processes in the apicomplexan Toxoplasma gondii
(2006-11-20)
The apicomplexan protozoan Toxoplasma gondii is a ubiquitous parasite of humans and animals. Entering its host through the digestive system, it possesses the ability to rapidly disseminate in the body and infect a wide ...
Host responses and bacterial virulence factors in Neisseria infections
(2004-08-27)
Neisseria meningitidis and Neisseria gonorrhoeae are human specific pathogens. N. meningitidis is a major cause of meningitis and sepsis, whilst N. gonorrhoeae causes many millions of cases of gonorrhea in the world every ...
Studies on fibronectin binding proteins, proteases, and virulence in Staphylococcus aureus
(2004-11-12)
Staphylococcus aureus produces several surface proteins, many of which bind specifically to different host extracellular matrix (ECM) proteins and plasma proteins, such as fibronectin, collagen and fibrinogen. Two highly ...
Analyses of genomic and gene expression signatures
(2004-08-20)
Biology has entered a challenging, information-intense period where computational experiments are complementing traditional experiments. A plethora of new techniques have allowed biological processes to be investigated on ...