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On gallstone disease : complications and surgical treatment
(2005-11-18)
Background: Gallstone disease is an important cause of morbidity in the Western world. Symptomatic gallbladder stones have been managed by cholecystectomy since 1882. After the introduction of laparoscopic cholecystectomy ...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
Background: Ultraviolet radiation (UVR) is considered one of the major risk factors for agerelated cataract. UVR-induced cataract follows a continuous dose-response function. The concepts maximum acceptable dose (MAD) and ...
Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases
(2006-05-02)
In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are ...
Humming, nitric oxide and paranasal sinus ventilation
(2006-04-21)
The paranasal sinuses are air-filled bony cavities surrounding the nose. They communicate with the nose via the sinus ostia through which fluid and gases pass in both directions. A proper ventilation is crucial for sinus ...
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
B. subtilis, A. aeolicus and a designed mutant LS from A. aeolicus (structure determined by cryo-EM in manuscript IV) were studied using small angle x-ray scattering (SAXS) and cryo-EM. The results indicate that multiple assembly states are a general...