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Structural diversity of the lipid A and core oligosaccharide moieties of the lipopolysaccharides from nontypeable and serotype f Haemophilus influenzae
(2005-11-04)
This thesis describes structural studies of the oligosaccharide and lipid A moieties of lipopolysaccharides (LPSs) isolated from disease-causing Haemophilus influenzae strains. The nontypeable strains were clinical isolates ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Epstein-Barr virus latency in vivo and in vitro
(2006-10-06)
In this thesis, I studied 1) The latency situation of Epstein- Barr virus (EBV) in bone marrow transplanted (BMT) patients and healthy virus carriers. 2) The role of EBNA1 and cellular transcriptional factors Oct and Grg/TLE ...
Peptic ulcer disease in an adult population : the Kalixanda study – a population-based endoscopic study
(2006-12-21)
Introduction: The pattern of symptoms and perception of disease among
patients seeking care does, due to health care seeking behaviour, most
probably not reflect the true health status in the general population.
Upper ...
Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity
(2005-08-12)
Psoriasis is a complex inflammatory skin disorder, affecting 2-3% of the population in the western world. The etiology of psoriasis is not yet known. However it is likely that its pathogenesis involves interplay between ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
initiation between 5th and 6th grade. A decreased risk of smoking uptake was associated with exposure to short anti-tobacco education before the 5th grade, compared to no education. Problematic interpersonal relations in the class were associated...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Translational studies of drug-induced tumor cell death
(2006-09-29)
It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ...
In vivo protein synthesis determinations in human immune cells
(2005-02-18)
in the isolated T lymphocytes of healthy volunteers was 13.6 ± 0.9 %/24 h and was not affected by a 6-h cortisol infusion, either immediately after the end of the infusion or 18 h later. In contrast, a combined stress hormone infusion (cortisol, epinephrine...
Cell damage and tissue repair in the central nervous system : electron mi[c]roscopy study of neuronal death and cell replacement
(2005-03-10)
The central nervous system is vulnerable to various insults and
particularly to ischemia. To mimic ischemia, a photochemical or
compression lesion was induced in the right sensory motor cortex of rat
brains. We studied ...