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Therapeutic myocardial angiogenesis and its pharmacological modulation
(2005-09-30)
double and phAng-1 had a similar effect. Transient overexpression of VEGF-A boosts angiogenesis at the arteriolar level more than at the capillary level. Combination with Ang-1 further boosts this effect and induced up to a 7.5 fold increase in vessel...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
and optimize CPA treatment.
In rats treated with single dose CPA (i.v.), the CYP2B1 and CYP2B2 mRNAs and the proteins CYP2B1/2 were significantly induced. Microsomal activity of CYP2B was significantly increased as well. The maximum levels of mRNA, proteins...
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(2005-05-27)
High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic...
Responsiveness of human circulating phagocytes in relation to the inflammatory condition
(2004-09-24)
to those from non-smokers. In addition patients and smokers also have vascular involvement as determined by elevated levels of sICAM1. There were no differences in adhesion molecule expression or mobilisation between the studied groups although smoking had...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
) boosters in non-responders were retrospectively analysed. Seroprotection was achieved in 1,517/1,840 (82.5%) vaccinees. Among non-responders, two-thirds had no detectable antibodies and one-third had levels of 1-9 IU/L (hypo-responders). In the group...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
c, Bid and Bax, as well as up-regulation of genes involved in erythroid differentiation (beta-globin, GATA-1 and DLK-1) in MDS CD34+ cells. Beta-globin was adequately expressed during erythroid maturation, while GATA-1 expression was significantly...
The epidemiology of low back pain in the general population and after motor vehicle collisions : population-based investigations
(2004-11-23)
the
incidence and course of LBP episodes in the general adult population.
Papers I and IV are based on the same study population. A random sample
of 2,055 Saskatchewan adults received a health survey and 1,133 (55.1%)
returned completed questionnaires...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
Background: Diabetes mellitus (DM) and impaired glucose tolerance test
(IGT) are well known risk factors for cardiovascular disease (CVD).
Individuals with IGT, a prediabetic state, are asymptomatic during many
years ...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
Obesity has become an important health problem worldwide. It increases
the medical risks and affects daily living. Environmental factors such as
diet and sedentary lifestyle are likely to be the cause. In Sweden, the
number ...
On the mind's time : production, perception, and pianists performance of rhythms : neural correlates and neuroanatomical changes
(2005-11-18)
Human movements are impressively flexible and precise. They are also coloured by the characteristics with which each person performs an act. This is evident in everyday activities, in sports, in art, and in music performance. ...